Intestinal metaplasia is usually the transformation of the epithelium in the stomach and esophagus into an intestinal type epithelium (metaplasia). In the esophagus, this condition is called the Barret esophagus. It is thought that inflammation caused by H. pylori infection in the stomach and gastroesophageal reflux disease in the esophagus are factors in the development of metaplasia. Goblet cells are observed in metaplastic epithelium mimicking intestinal type epithelium.