In genetic engineering, a gene gun or biolistic particle delivery system is a device used to transfer exogenous DNA (transgenes), RNA or protein to cells. First, heavy metal particles are coated with the gene of interest. Then, these micro bullets are fired into the cells using mechanical force. Thus, the integration of the desired genetic information into target cells is achieved. Techniques involved in this type of micro-bullet application of DNA are often referred to as biolistics. This device can target almost any type of cell and is not limited to the transformation of the nucleus only; It can also target organelles, including plastids and mitochondria.